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An invasive biopsy followed by histological staining is the gold standard for traditional pathological identification of skin cancers, which requires a long processing time and often results in undesired biopsies and scarring. Reflectance confocal microscopy (RCM) can provide biopsy-free in vivo images of skin structure with a cellular-level resolution for skin disease evaluation; however, the RCM images are grayscale, miss nuclear features and have a low correlation with pathology, which requires specialized training for interpretation. Here, we report a deep learning-based method for performing non-invasive virtual skin histology using in vivo, label-free RCM images.more » « less
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